- Title
- Development of an UHPLC-MS/MS method for remifentanil quantification in a small plasma volume
- Creator
- O'Hara, Kate; Schneider, Jennifer J.; Jones, Alison L.; Wright, Ian M. R.; Martin, Jennifer H.; Galettis, Peter
- Relation
- Journal of Liquid Chromatography and Related Technologies Vol. 42, Issue 15-16, p. 521-527
- Publisher Link
- http://dx.doi.org/10.1080/10826076.2019.1631178
- Publisher
- Taylor & Francis
- Resource Type
- journal article
- Date
- 2019
- Description
- Remifentanil is a short acting opioid currently used in anesthesia and as an analgesic. This paper describes a simple, fast HPLC-MS/MS methodology that allows detection of remifentanil in low volume plasma samples. Acetonitrile protein precipitation is used for sample extraction and clean up. The assay has a lower limit of detection of 0.25 ng/mL and a 3 min run time.
- Subject
- HPLC-MS/MS; LC-MS/MS; microassay; neonate; pharmacokinetics; remifentanil
- Identifier
- http://hdl.handle.net/1959.13/1463954
- Identifier
- uon:46877
- Identifier
- ISSN:1082-6076
- Language
- eng
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